HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 1-(Benzothiophen-2-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-Chlorobenzothiazole | HCID 11987 | — |
| Product | 1-(Benzothiophen-2-yl)piperazine | HCID 19064974 | — |
Reaction Steps
2-Chlorobenzothiazole (5 g) is heated in ethanol (75 ml) with piperazine (3.05 g) for 20 h. The mixture is partitioned between methylene chloride/ether and aqueous sodium bicarbonate. The organic phase is separated, dried with sodium sulfate and concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05268477 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-cf6e58f316fc4292a59846c68dcba790 |
| Source note | uspto-grants-1993_12 |