HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 54339148, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone | HCID 6775 | — |
| Reactant | 16-Methylprogesterone | HCID 134874 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 54339148 | HCID 54339148 | — |
Reaction Steps
A mixture of 16α-methylprogesterone (792 mg), DDQ (575 mg) and benzene are heated at reflux for 28 hr, after 20 hr additional DDQ (70 mg) is added. After refluxing, the mixture is cooled to 20°-25°, filtered followed by basic workup (ether-potassium carbonate-magnesium sulfate) to give 16α-methylpregna-1,4-diene-3,20-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05268477 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-84e85e9de80045c1b8a9e11396d1d066 |
| Source note | uspto-grants-1993_12 |