1-(3-Chlorophenyl)piperazine → HCID 15230689, compound

HRID 326505Notes

Reaction equation

HRID 326505 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.I[CH2:15][C:16](=[O:38])[C@@H:17]1[C@:34]2([CH3:35])[C@H:20]([C@H:21]3[C:31](=[CH:32][CH2:33]2)[C@:29]2([CH3:30])[C:24](=[CH:25][C:26](=[O:36])[CH:27]=[CH:28]2)[CH2:23][CH2:22]3)[CH2:19][C@H:18]1[CH3:37]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:15][C:16](=[O:38])[C@@H:17]3[C@:34]4([CH3:35])[C@H:20]([C@H:21]5[C:31](=[CH:32][CH2:33]4)[C@:29]4([CH3:30])[C:24](=[CH:25][C:26](=[O:36])[CH:27]=[CH:28]4)[CH2:23][CH2:22]5)[CH2:19][C@H:18]3[CH3:37])[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 14878745HCID 14878745, compound

Product 1

HCID 15230689HCID 15230689, compound

Procedure

Following the general procedure of EXAMPLES 1-6A, 7, 8, 11-19, 83, 126 and 139 and making non-critical variations but starting with 4-(3-chlorophenyl)piperazine (PREPARATION A-57) and 21-iodo-16αmethylpregna-1,4,9(11)-triene-3,20-dione (PREPARATION S-22), the title compound is obtained.

Sources & evidence

ORD record
ord-bd9483b231ad4a579cb4f563c81903f8
Source dataset
uspto-grants-1993_12
Patent number
US05268477

Reaction notes

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