Hydrogen Bromide → HCID 15027123, compound

Participants

Reaction Conditions

Reaction Steps

In a 200 ml-round-bottomed flask, 8.20 g (21.6 mM) of 2-(4-octylphenyl)-5-(4-methoxyphenyl)thiazole, 80 ml of a solution of 25%-hydrogen bromide in acetic acid and 3 ml of 57%-hydroiodic acid were placed, followed by heat-stirring for 20 hours at 100° C. After the reaction, the reaction mixture was poured into 200 ml of water, followed by extraction with chloroform. The organic layer was washed with water and dried with anhydrous sodium sulfate, followed by distilling-off of the solvent under reduced pressure. The residue was purified by silica gel column chromatography (eluent: chloroform/ethyl acetate=20/1) to obtain 1.80 g of 2-(4-octylphenyl)-5-(4-hydroxyphenyl)thiazole (Yield: 22.8%).

Provenance & Evidence