Potassium Hydroxide → HCID 3440162, compound

HRID 326527Notes

Reaction equation

HRID 326527 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][CH:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:13]([O:15]C)=[O:14])[N:4]=1.[OH-].[K+]>O.C(O)C>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([O:11][CH:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:13]([OH:15])=[O:14])[N:6]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 15630567HCID 15630567, compound

Product 1

HCID 3440162HCID 3440162, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

5 g (16 mmol) Methyl 2-(4,6-dimethoxy-2-pyrimidinyloxy)-2-phenylacetate was dissolved in 50 ml water/ethanol (1:1) and treated with 0.9 g potassium hydroxide. After stirring for 16 hours at room temperature, the mixture was extracted with ethyl acetate. The aqueous phase was acidified with 10% hydrochloric acid until it was pH 2 and extracted with ethyl acetate. After drying over magnesium sulphate, the ethyl acetate phase was concentrated the solid residue recrystallised from diisopropyl ether/ethyl acetate mixture.

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. extractionextracted with ethyl acetate
  3. dry with materialAfter drying over magnesium sulphate
  4. concentrationthe ethyl acetate phase was concentrated the solid residue
  5. customrecrystallised from diisopropyl ether/ethyl acetate mixture

Sources & evidence

ORD record
ord-5c2c12a017ef4a4ba73c7be73316d832
Source dataset
uspto-grants-1993_12
Patent number
US05270289

Reaction notes

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