HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 3-Fluoro4-piperazin-1-yl-benzoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Ethyl 3,4-difluorobenzoate | HCID 2737171 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 3-Fluoro4-piperazin-1-yl-benzoic acid ethyl ester | HCID 20785616 | 91% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A mixture of 5 g (27 mmol) 3,4-Difluoro-benzoic acid ethyl ester and 11.56 g (134 mmol) piperazine in 15 ml N,N-dimethylacetamide was heated to 120° C. for 1.5 h and subsequently all volatiles were removed under vacuum. The residue was purified by flash column chromatography on silica eluting with DCM/methanol to yield 6.19 g (91%) of the title compound as white amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427612B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-7151b83423b9479088be4fb95fde9d42 |
| Source note | uspto-grants-2008_09 |