Methyl iodide → HCID 19735558, compound

Participants

Reaction Steps

After 1.20 g (6.32 mmol) of Compound 24 obtained in Example 24 was suspended in 20 ml of dimethylformamide, 0.265 g (6.63 mmol) of 60% sodium hydride was added to the suspension at 0° C. After 30 minutes, 0.433 ml (6.95 mmol) of iodomethane was added and the mixture was stirred at room temperature for 1.5 hours. The precipitate was collected by filtration and recrystallized from isopropanoldiisopropyl ether to afford 0.700 g (54.3%) of Compound 25 as colorless crystals.

Provenance & Evidence