Butyl iodide → HCID 19735583, compound

Participants

Reaction Steps

After 1.20 g (6.32 mmol) of Compound 24 obtained in Example 24 was suspended in 20 ml of dimethylformamide, 0.265 g (6.63 mmol) of 60% sodium hydride was added to the suspension at 0° C. After 30 minutes, 0.755 ml (6.63 mmol) of iodobutane was added and the mixture was stirred at room temperature for 1.5 hours. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluting solvent; chloroform:methanol=40:1) to afford 1.10 g (70.8%) of Compound 26 as white crystals.

Provenance & Evidence