Butyl iodide → HCID 19735584, compound

Participants

Reaction Steps

To a suspension of 2-chloro-7-methyl-1,7-dihydro-6H-purin-6-one [Ber., 30, 2400 (1897)] (6.68 g, 0.0362 mol) was added 2.03 g (0.0507 mol) of 60% sodium hydride, and the mixture was stirred for 30 minutes. To the mixture was added 8.24 ml (0.0724 mol) of iodobutane. The mixture was stirred at an external temperature of 65° C. for further 30 minutes. The solvent was evaporated under reduced pressure and the obtained residue was purified by silica gel column chromatography (eluting solvent: chloroform:methanol=20:1) to afford 5.38 g (61.8%) of Compound j as light yellow crystals.

Provenance & Evidence