Hydrochloric Acid → HCID 178518538, compound

Participants

Reaction Steps

2.00 g (11.9 mmol) of 2-mercapto-6-hydroxypurine was dissolved in a solvent mixture of 10 ml of ethanol, 10.9 ml of 2N sodium hydroxide and 15 ml of water. Under ice cooling with stirring, 2.06 ml (17.9 mmol) of benzylbromide was added to the solution, following stirring at room temperature for 30 minutes. Again under ice cooling, the mixture was neutralized with 2N hydrochloric acid and 30 ml of n-hexane was added to the mixture. A precipitated was collected by filtration, washed with ethyl acetate and dried to afford 1.32 g (yield, 45%) of 2-benzylthio-6-hydroxypurine as a crude product.

Provenance & Evidence