Methyl iodide → HCID 19735547, compound

Participants

Reaction Conditions

Reaction Steps

After 500 mg (0.10 mmol) of Compound o obtained in Reference Example 14 was dissolved in 20 ml of tetrahydrofuran, 0.08 g (0.20 mmol) of 60% sodium hydroxide was added to the solution under ice cooling. After 30 minutes, 0.125 ml (0.20 mmol) of methyliodide was added, and the mixture was stirred for 2 hours at 50° C. The solvent was evaporated under reduced pressure, and water was added to the residue. The mixture was extracted with chloroform, and the extract was washed with a saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and filtered. The solvent was evaporated under reduced pressure, and the residue was purified by silicagelcolumchromatography (eluent: chloroform) to afford 300 mg (yield, 58%) of Compound p as a white powder.

Provenance & Evidence