Methyl iodide → HCID 19735108, compound

HRID 326587Notes

Reaction equation

HRID 326587 reaction equation
[CH3:1][I:2].[C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:13][C:12]([CH3:15])([CH3:14])[N:11]=[C:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)[C:9]=2[CH:22]=1)#[N:4]>C(#N)C>[I-:2].[C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:13][C:12]([CH3:15])([CH3:14])[N:11]=[C:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N+:17]=3[CH3:1])[C:9]=2[CH:22]=1)#[N:4]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 10611577HCID 10611577, compound

Product 1

HCID 19735108HCID 19735108, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Methyliodide (2 ml) was added to a solution of 6-cyano-2,2-dimethyl-4-(2-pyridyl)-2H-1,3-benzoxazine (0.20 g) in acetonitrile (14 ml) and the mixture was heated under reflux for 7 hours. After air-cooling, the solvent was distilled off under reduced pressure and the residue was crystallized from diethyl ether to obtain 2-(6-cyano-2,2-dimethyl-2H-1,3-benzoxazin-4-yl)-1-methylpyridinium iodide (0.29 g) (Compound 18).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 7 hours
  3. temperatureAfter air-cooling
  4. distillationthe solvent was distilled off under reduced pressure
  5. customthe residue was crystallized from diethyl ether

Sources & evidence

ORD record
ord-41f15e62a600472a92cdd1690a2eece3
Source dataset
uspto-grants-1993_12
Patent number
US05270308

Reaction notes

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