Sodium Hydroxide → 7-Ethyl-4-oxo-1,4-dihydroquinoline-2-carboxylic acid

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Reaction Steps

Treatment of methyl 7-ethyl-4-oxo-1,4-dihydroquinoline-2-carboxylate (0.8 g, Example 3a) with sodium hydroxide (0.58 g) as described in Example 1c, gave 7-ethyl-4-oxo-1,4-dihydroquinoline-2-carboxylic acid (0.66g), m.p. 271° C., δ (360 MHz, NaOD) 1.30 (3H, t, CH3), 2.81 (2H, q, CH2), 6.66 (1H, s, 3-H), 7.36 (1H, d, 6-H), 7.66 (1H, s, 8-H) and 8.11 (1H, d, 5-H), (Found: C, 66.46: H, 5.01; N, 6.59%, C12H11NO3 requires C, 66.35; H, 5.10: N, 6.45%).

Provenance & Evidence