Sodium Hydroxide → 7-Bromo-5-methyl-4-oxo-1,4-dihydroquinoline-2-carboxylic acid

Participants

Reaction Steps

A solution of methyl-7-bromo-5-methyl-4-oxo-1,4-dihydroquinoline-2-carboxylate (0.40 g) in water (10 ml) containing sodium hydroxide (0.22 g) was refluxed for 10 minutes, then acidified with cHCl. The precipitate was collected and recrystallised from H2O/EtOH/NaOH on addition of cHCl to give 7-bromo-5-methyl-4-oxo-1,4-dihydroquinoline-2-carboxylic acid (0.35 g), mp 299° C. (dec.). m/e 283, 281 (M+); δ (360 MHz, NaOD-D2O) 2.86 (3H, s, CH3), 6.85 (1H, s, 3-H), 7.22 (1H, d, 6-H) and 7.83 (1H. d, 8-H).

Provenance & Evidence