HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 123158-30-5
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 4-hydroxy-6-(trifluoromethyl)quinoline-2-carboxylate | HCID 2741057 | — |
| Product | 123158-30-5 | HCID 14842744 | 44.3% |
Reaction Steps
Treatment of methyl 6-trifluromethyl-4-oxo-1,4-dihydroquinoline-2-carboxylate (0.5 g. Example 19a) with sodium hydroxide (0.295 g), as described in Example 1c, gave 6-trifluoromethyl-4-oxo-1,4-dihydroquinoline-2-carboxylic acid (0.21 g), m.p. 287°-289° C., δ (360 MHz, DMSO-d6) 6.72 (1H, s, 3-H), 8.01 (1H, dd, 7-H), 8.14 (1H, d, 8-H), 8.33 (1H, s, 5-H). (Found: C, 49.11; H. 2.79; N, 5.12%; C11H6NO3. 0.75H2O requires C, 48.81; H, 2.79; N, 5.17%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05270309 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-08b30e2661e44e0199667f5ecab42648 |
| Source note | uspto-grants-1993_12 |