Dimethyl acetylenedicarboxylate → HCID 619331, compound

Participants

Reaction Steps

Using the method described in Example 18a with 4-methylthioaniline (20 g) and dimethyl-acetylene dicarboxylate (20.21 g) as reagents gave methyl 6-methylthio-4-oxo-1,4-dihydroquinoline-2-carboxylate (10.12 g), m.p. 264°-266° C. δ (360 MHz, DMSO-d6), 2.55 (3H, s, CH3S), 3.96 (3H, s, CH3O), 6.68 (1H, s, 3-H), 7.64 (1H, dd, 7-H), 7.83 (1H, d, 5-H) and 7.89 (1H, d, 8-H).

Provenance & Evidence