Sodium Hydroxide → HCID 14842737, compound

HRID 326636Notes

Reaction equation

HRID 326636 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[C:8]2[C:3]=1[C:4](=[O:17])[CH:5]=[C:6]([C:13]([O:15]C)=[O:14])[NH:7]2.[OH-].[Na+]>>[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[C:8]2[C:3]=1[C:4](=[O:17])[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[NH:7]2

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 19735188HCID 19735188, compound

Product 1

HCID 14842737HCID 14842737, compoundYield 85.2%

Procedure

Treatment of methyl 5,7-dimethyl-4-oxo-1,4-dihydroquinoline-2-carboxylate (1 g) with sodium hydroxide (0.69 g), as described in Example 1c, gave 5,7-dimethyl-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid (0.8 g), m.p. 285°-287° C., δ (360 MHz,DMSO-d6) 2.33 (3H, s, 7-Me), 2.75 (3H. s, 5-Me), 6.49 (1H, s, 3-H), 6.87 (1H, s, 6-H) and 7.55 (1H, s, 8-H). (Found: C, 66.53; H, 4.96; N, 6.72%. C12H11NO3 requires C, 66.35; H, 5.10; N,6. 45%).

Sources & evidence

ORD record
ord-666f42af54e0409bb060d732e81b4109
Source dataset
uspto-grants-1993_12
Patent number
US05270309

Reaction notes

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