Hydrochloric Acid → HCID 14842740, compound

Participants

Reaction Steps

Treatment of ethyl 7-chloro-5-ethyl-4-oxo-1,4-dihydroquinoline-2-carboxylate (250 mg) with 2M is NAOH (1.5 ml) in DMF at room temperature for 76 h, followed by acidification with HCl, gave 7-chloro-5-ethyl-4-oxo-1,4-dihydroquinoline-2-carboxylic acid (222 mg), mp 282°-283° C. δ (360 MHz, DMSO-d6) 1.15 (3H, t, CH3), 3.26 (2H, q, CH2), 6.55 (1H, s, 3-H), 7.10 (1H, d, 6-H), 7.88 (1H, d, 8-H) and 11.78 (1H, bs, NH).

Provenance & Evidence