Methyl iodide → HCID 19735181, compound

Participants

Reaction Steps

To a suspension of 5,7-dichloro-2-(2-dimethylaminoethyl)carbamoyl-4-oxo-1,4-dihydroquinoline (0.5 g, Example 39) in dry dimethylformamide was added methyl iodide and the mixture was stirred at room temperature for 24 hours. The solvent was removed under reduced pressure to yield the crude product, which was recrystallised from ethanol-water to give 5,7-dichloro-2-(2-trimethylammonioethyl)carbamoyl-4-oxo-1,4-dihydroquinoline iodide (0.39 g), m.p.>280° C. δ (360 MHz, D2O) 3.26 (9H, s, (CH3)3), 3.62 (2H, t, CH2N), 3.94 (2H, t, CONHCH2), 6.78 (1H, s, 3-H), 7.50 (1H, d, 6-H) and 7.76 (1H, d, 8-H), (Found: C, 37.06; H, 3.91; N, 8.65; I, 26.14%. C15H18Cl2IN3O2 requires C, 36.98; H, 3.91; N, 8.62; I, 26.02%).

Provenance & Evidence