HCID 15408557, compound → HCID 10583768, compound

HRID 326668Notes

Reaction equation

HRID 326668 reaction equation
[CH2:1]([CH:5]([CH2:16][C:17]([O:19][CH3:20])=[O:18])[C:6]([O:8]CC1C=CC=CC=1)=[O:7])[CH:2]([CH3:4])[CH3:3].[H][H]>[Pd].CO>[CH2:1]([CH:5]([CH2:16][C:17]([O:19][CH3:20])=[O:18])[C:6]([OH:8])=[O:7])[CH:2]([CH3:4])[CH3:3]

Participants

5

Reactant 2

HCID 15408557HCID 15408557, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 10583768HCID 10583768, compoundYield 86.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 8.01 g (0.029 mol) of (2) and 1 g of 10% palladium on carbon in 50 mL of methanol was hydrogenated at room temperature under 4 atmospheres of hydrogen gas for 8 hr. After removal of the catalyst by filtration the filtrate was evaporated to dryness under reduced pressure to give 4.7 g (86% yield) of 2-isobutyl-3-(methoxycarbonyl)-propionic acid (3) as a colorless oil.

Workup

  1. customAfter removal of the catalyst
  2. filtrationby filtration the filtrate
  3. customwas evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-76500c49e6c0409989aec42254b34812
Source dataset
uspto-grants-1993_12
Patent number
US05270326

Reaction notes

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