反应详情

21.0 g (86 mMol) of 2-n-propyl-3-ethoxycarbonyl-8-methylimidazo[1,2-a]pyridine are dissolved in 200 ml of ethanol, mixed with 100 ml of 2N sodium hydroxide solution and stirred for 4 days at ambient temperature. The solvent is evaporated off in vacuo at 40° C., the residue is diluted with water and combined with 20 g of ammonium chloride. The pH is adjusted to 6.5 by the addition of glacial acetic acid. After 2 hours, the precipitate formed is suction filtered, washed with water and dried in vacuo at 40° C.

1. customThe solvent is evaporated off in vacuo at 40° C.
2. additionthe residue is diluted with water
3. additionThe pH is adjusted to 6.5 by the addition of glacial acetic acid
4. waitAfter 2 hours
5. customthe precipitate formed
6. filtrationfiltered
7. washwashed with water
8. customdried in vacuo at 40° C.