Formamidine acetate → HCID 19735511, compound

Participants

Reaction Steps

5.97 g of formamidine acetate were added to a solution of 3.96 g of Na and 100 ml of absolute methanol. After cooling, the solution to 10° C. 15.51 g of diethyl (m-chlorophenyl)malonate were added in portions. After 2.5 hours, the solvent was evaporated under reduced pressure. The residue was dissolved in water and the solution was adjusted to pH 5.0 with glacial acetic acid. The resulting precipitate was removed by filtration under suction, washed with water, ethanol and ether and dried at 70° C. under reduced pressure. There was obtained 5-(m-chlorophenyl)-4,6(1H,5H)-pyrimidinedione which was used directly in the next step.

Provenance & Evidence