Sodium borohydride → HCID 19735302, compound

Participants

Reaction Steps

53 mg of rac-p-[[5-(o-methoxybenzyl)-6-[2-[(tetrahydro-2H-pyran-2-yl]oxy]ethoxy]-4-pyrimidinyl]sulfamoyl]benzalde-hyde were dissolved in 3 ml of methyl alcohol and treated with 37 mg of sodium borohydride at room temperature. After stirring at room temperature for 1 hour, the methanol was evaporated under reduced pressure. The residue was dissolved in ethyl acetate, washed with water and NaCl solution (saturated), dried and distilled under reduced pressure. There were obtained 42 mg of rac-α-hydroxy-N-[5-(o-methoxybenzyl)-6-[2-[(tetra-hydro-2H-pyran-2-yl)oxy]ethoxy]-4-pyrimidinyl]-p-toluene-sulfonamide as a colorless oil. MS: 529 (M); 445 (tetrahydro-2H-pyran-2-yl); 434 (--OCH3 +SO2).

Provenance & Evidence