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4,6-Dichloro-5-(4-methoxyphenyl)pyrimidine → N-[6-chloro-5-(p-methoxyphenyl)-4-pyrimidinyl]-p-methoxybenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,6-Dichloro-5-(4-methoxyphenyl)pyrimidine | HCID 19735458 | — |
| 反応物 | p-Methoxybenzenesulfonamide potassium | HCID 67861510 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-[6-chloro-5-(p-methoxyphenyl)-4-pyrimidinyl]-p-methoxybenzenesulfonamide | HCID 19735332 | 85% |
反応手順
A solution of 510 mg of 4,6-dichloro-5-(p-methoxyphenyl)pyrimidine and 680 mg of p-methoxybenzenesulfonamide potassium in 3 ml of dimethylformamide was heated at 130° C. for 1 hour. After working-up the reaction mixture, there were obtained 690 mg of N-[6-chloro-5-(p-methoxyphenyl)-4-pyrimidinyl]-p-methoxybenzenesulfonamide, melting point 165°-167° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05270313 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-ef826bf849a543819c621b91bbb063fc |
| 出典メモ | uspto-grants-1993_12 |