HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamidine → 5-(o-chlorobenzyl)-6-hydroxy-4(3H)-pyrimidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamidine | HCID 68047 | — |
| Reactant | Diethyl 2-(2-chlorobenzyl)malonate | HCID 12661049 | — |
| Product | 5-(o-chlorobenzyl)-6-hydroxy-4(3H)-pyrimidinone | HCID 19735337 | — |
Reaction Steps
Condensation of diethyl o-chlorobenzylmalonate with formamidine yielded 5-(o-chlorobenzyl)-6-hydroxy-4(3H)-pyrimidinone which, by reaction with phosphorus oxychloride, yielded 4,6-chloro-5-(o-chlorobenzyl)pyrimidine, melting point 110°-112° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05270313 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-938cb0896f2a4a44bf376abc087d4d14 |
| Source note | uspto-grants-1993_12 |