HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Hydroxysuccinimide → HCID 17921840, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Hydroxysuccinimide | HCID 80170 | — |
| Reactant | 3-(3-Pyridinyl)-2-propenoic acid | HCID 101984 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 17921840 | HCID 17921840 | — |
Reaction Steps
A solution of 3-(3-pyridyl)acrylic acid (500 mg: commercially available from Aldrich Chemical Company), N-hydroxysuccinimide (463 mg), and EDCl (707 mg) in methylene chloride (20 mL) and DMF (10 mL) was stirred at ambient temperature for 18 hours. The product was isolated as described in Example 3a to yield 740 mg of the title compound as a white solid. MS (Cl/NH3) m/e 247 (M+H)+. 1H NMR(CDCl3, 300 MHz) δ2.87 (br s,4H), 7.15 (d,J=16 Hz,1H), 7.48-7.53 (m,1H), 8.02 (d,1H), 8.31 (dt,J=9 Hz,1H), 8.66 (dd,J=6 Hz,1H), 8.99 (d,J=2 Hz,1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05270302 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-e6757b0d73aa4c60add2f432af649b97 |
| Source note | uspto-grants-1993_12 |