Potassium Hydroxide → HCID 22102325, compound

Participants

Reaction Steps

Ethyl 2-carboethoxy-3-(3-indolyl)-2-methylpropionate (1.8 g, 5.95 mmol) (S. Masanori, et al., Heterocycles, 1981, 16:941-9), was added to a solution of potassium hydroxide (380 mg, 5.76 mmol) in 4 mL of ethanol. The reaction mixture was stirred at ambient temperature overnight and then heated on a steam bath for 2 hours. The ethanol was evaporated and water (20 mL) was added. The aqueous mixture was extracted with diethyl ether (3×20 mL). The pH of the aqueous layer was adjusted to approximately 1 and it was then extracted with ethyl acetate. The ethyl acetate solution was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to give 1.5 g (92% yield) of the title compound.

Provenance & Evidence