HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride → 1-(5,6-Dichloroindan-1-carbonyl)-4-methyl-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride | HCID 18915109 | — |
| Reactant | 5,6-Dichloroindan-1-carbonyl chloride | HCID 18915166 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(5,6-Dichloroindan-1-carbonyl)-4-methyl-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride | HCID 18915043 | 109.2% |
Reaction Steps
The procedure described in Example 24 was repeated, but using 1.67 g of 1-methyl-3-(pyrrolidin-1-ylmethyl)-piperazine trihydrochloride, 3.6 ml of triethylamine and 1.5 g of 5,6-dichloroindan-1-carbonyl chloride, to afford 1.54 g of the title compound, melting at 245°-250° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05270327 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-7058ad8b93ad412da8e09fc1825e8e6f |
| Source note | uspto-grants-1993_12 |