HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Pyrrolidin-1-ylmethyl)morpholine → 4-(5-Chloro-3-oxoindan-1-carbonyl)-3-(pyrrolidin-1-ylmethyl)morpholine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Pyrrolidin-1-ylmethyl)morpholine | HCID 18915061 | — |
| Reactant | HCID 18915111 | HCID 18915111 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 4-(5-Chloro-3-oxoindan-1-carbonyl)-3-(pyrrolidin-1-ylmethyl)morpholine hydrochloride | HCID 18915003 | 104.6% |
Reaction Steps
The procedure described in Example 24 was repeated, but using 0.89 g of 3-(pyrrolidin-1-ylmethyl)morpholine, 2.0 ml of triethylamine and 0.91 g of 5-chloro-3-oxo-indan-1-carbonyl chloride, to afford 0.83 g of the title compound, melting at 220°-229° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05270327 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-67903700b758424e8d2a1831ad92cdde |
| Source note | uspto-grants-1993_12 |