Morpholine → 2-Chloro-5-(morpholine-4-sulfonyl)-benzoic acid

HRID 32675Notes

Reaction equation

HRID 32675 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11](=[O:15])(=[O:14])[NH:12][CH3:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].ClC1C=CC(S(O)=O)=CC=1C(O)=O.N1C[CH2:33][O:32][CH2:31][CH2:30]1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([N:12]2[CH2:30][CH2:31][O:32][CH2:33][CH2:13]2)(=[O:15])=[O:14])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

4

Reactant 3

HCID 8083MorpholineHCID 111724Benzoic acid, 2-chloro-5-[(methylamino)sulfonyl]-HCID 151129042-Chloro-5-sulfino-benzoic acid

Product 1

HCID 7678962-Chloro-5-(morpholine-4-sulfonyl)-benzoic acidYield 100%

Procedure

The title compound was synthesised according to the procedure described for 2-Chloro-5-methylsulfamoyl-benzoic acid from 2-Chloro-5-sulfino-benzoic acid and morpholine and obtained in 100% yield. MS (m/e): 304.0 (MH−, 100%).

Workup

  1. customobtained in 100% yield

Sources & evidence

ORD record
ord-91c1c054f63d499c9c608507ca82abef
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Reaction notes

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