HRID326762

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7187

Benzoyl peroxide

C14H10O4

HCID67184

1-Bromopyrrolidine-2,5-dione

C4H4BrNO2

HCID10152019

5-(4'-Methyl[1,1'-biphenyl]-2-yl)-1-(triphenylmethyl)-1H-tetrazole

C33H26N4

PRODUCTS

产物

HCID10053461

5-[4'-(Bromomethyl)[1,1'-biphenyl]-2-yl]-1-(triphenylmethyl)-1H-tetrazole

C33H25BrN4

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID5943

Carbon tetrachloride

CCl4

PROCEDURE

实验过程

A mixture containing 11 g of the compound prepared in step B, 140 ml of carbon tetrachloride, 4.12 g of NBS and 0.4 g of benzoyl peroxide is refluxed for 3 hours. After it has returned to RT, it is filtered and the filtrate is then evaporated. The residue is taken up in 30 ml of isopropyl ether. The precipitate formed is filtered off and then dried under vacuum.

WORKUP

后处理

temperatureis refluxed for 3 hours
customhas returned to RT
filtrationit is filtered
customthe filtrate is then evaporated
customThe precipitate formed
filtrationis filtered off
customdried under vacuum

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-4ff322cc18054db99e37836cb168c249
来源数据集: uspto-grants-1993_12
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05270317
来源说明: uspto-grants-1993_12

反应SMILES

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[C:14]2[N:18]([C:19]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:17]=[N:16][N:15]=2)=[CH:4][CH:3]=1.C1C(=O)N([Br:45])C(=O)C1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:45][CH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[C:14]2[N:18]([C:19]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:17]=[N:16][N:15]=2)=[CH:6][CH:7]=1