Methanol → 2-(4-Fluorophenyl)-4-(3-trifluoromethylphenyl)-5-methoxypyrimidine

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	Sodium Methoxide	HCID 10942334	—
Reactant	2-(4-Fluorophenyl)-4-(3-trifluoromethylphenyl)-5-methanesulfonylpyrimidine	HCID 14883670	—
Solvent	1,2-Dimethoxyethane	HCID 8071	—
Product	2-(4-Fluorophenyl)-4-(3-trifluoromethylphenyl)-5-methoxypyrimidine	HCID 11725302	85.3%

Reaction Steps

2 g of 2-(4-fluorophenyl)-4-(3-trifluoromethylphenyl)-5-methanesulfonylpyrimidine, 0.3 g of sodium methoxide and 20 ml of methanol were added to 120 ml of ethylene glycol dimethyl ether, and the resulting mixture was heated under reflux for 5 hours. The solvent was distilled away under reduced pressure. The residue was washed with water, and then dried to obtain 1.5 g of 2-(4-fluorophenyl)-4-(3-trifluoromethylphenyl)-5-methoxypyrimidine (Compound 18).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05270467
Source dataset	uspto-grants-1993_12
ORD ID	ord-a1582ad8349749fab13fbecf2389449c
Source note	uspto-grants-1993_12