Acetic Anhydride → HCID 178475914, compound

HRID 326830Notes

Reaction equation

HRID 326830 reaction equation
[NH2:1][C:2]1[C:3]([C:9]([NH2:11])=[O:10])=[N:4][CH:5]=[C:6]([OH:8])[N:7]=1.[C:12]([O:15][C:16](=O)[CH3:17])(=[O:14])[CH3:13]>C(O)C.CN(C)C=O>[C:12]([O:15][CH2:16][C:17]1[NH:11][C:9](=[O:10])[C:3]2[C:2](=[N:7][C:6]([OH:8])=[CH:5][N:4]=2)[N:1]=1)(=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 1785138073-Amino-5-oxo-4,5-dihydropyrazine-2-carboxamide

Product 1

HCID 178475914HCID 178475914, compound

Reagents, catalysts & solvents 1

HCID 19794673N,N-dimethylformamide ethanolSolvent

Procedure

Obtained using the procedure described in Example 1, starting with 5.0 g (0.0324 mole) of 3-amino-5-hydroxy-2-pyrazinecarboxamide, 29.5 g (0.134 mole) of triethyl orthoacetoxyacetate and 9.5 ml of acetic anhydride. Refluxing time: 1 hour 45 minutes. Yld: 3.8 g (50%), m.p.>300° C. (ethanol/N,N-dimethylformamide).

Workup

  1. customObtained
  2. temperatureRefluxing time
  3. custom1 hour 45 minutes

Sources & evidence

ORD record
ord-066ac02921a047438b3253352ad1f7a4
Source dataset
uspto-grants-1993_12
Patent number
US05270465

Reaction notes

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