Ethanol → Ethyl 2-(2,3-dichlorophenoxy)acetimidate hydrochloride

Participants

Reaction Steps

Obtained using the procedure described in section a of Example 6, starting with 219.8 g (1.086 moles) of (2,3-dichlorophenoxy)acetonitrile [prepared according to R. W. Fuller et al., J. Med. Chem. 1973, 16, 101] and 50.0 g (1.086 moles) of absolute ethanol in 1750 ml of ether. Reaction time: 16 hours at 0° C. Yld: 293.5 g (95%), m.p. 167°-169° C.

Provenance & Evidence