反应详情

Obtained using the procedure described in section c of Example 2, starting with 12.0 g )0.10 mole) of 3-amino-2-pyrazinecarbonitrile and 25.0 g (0.15 mole) of 2-(benzyloxy)acetamidine [prepared according to W. J. Haggerty Jr. and W. J. Rost, J. Pharm. Sci. 1969, 58, 50] in 400 ml of absolute ethanol. Refluxing time: 4 hours. Yld: 15.4 g (58%), m.p. 112°-114° C. An analytical sample was obtained by recrystallization from ethanol, followed by washing with dilute hydrochloric acid and finally recrystallization from ethyl acetate. M.p. 131°-133° C.

1. customObtained
2. temperatureRefluxing time
3. custom4 hours
4. washby washing with dilute hydrochloric acid and finally recrystallization from ethyl acetate