Ammonia → 2-(2,2,2-Trifluoroethoxy)acetamidine

HRID 326847Notes

Reaction equation

HRID 326847 reaction equation
[F:1][C:2]([F:11])([F:10])[CH2:3][O:4][CH2:5][C:6](=[NH:9])OC.[NH3:12]>C(O)C>[F:1][C:2]([F:11])([F:10])[CH2:3][O:4][CH2:5][C:6]([NH2:12])=[NH:9]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14880139Methyl 2-(2,2,2-trifluoroethoxy)acetimidate

Product 1

HCID 105830132-(2,2,2-Trifluoroethoxy)acetamidine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Obtained using the procedure described in section b of Example 2, starting with 15.6 g (0.091 mole) of methyl 2-(2,2,2-trifluoroethoxy)acetimidate and 7.7 g (0.455 mole) of ammonia in 225 ml of absolute ethanol. Reaction time: 24 hours. Yld: 14.2 g (quantitative).

Workup

  1. customObtained
  2. customReaction time
  3. custom24 hours

Sources & evidence

ORD record
ord-69547faa290b40cf82587ba21b72c504
Source dataset
uspto-grants-1993_12
Patent number
US05270465

Reaction notes

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