3-Aminopyrazine-2-carbonitrile → HCID 10543796, compound

HRID 326853Notes

Reaction equation

HRID 326853 reaction equation
[NH2:1][C:2]1[C:3]([C:8]#[N:9])=[N:4][CH:5]=[CH:6][N:7]=1.[Cl:10][C:11]1[CH:12]=[C:13]([CH:19]=[CH:20][C:21]=1[Cl:22])[O:14][CH2:15][C:16](N)=[NH:17].C(O)C.CN(C)C=O>C(O)C>[NH2:9][C:8]1[C:3]2[C:2](=[N:7][CH:6]=[CH:5][N:4]=2)[N:1]=[C:16]([CH2:15][O:14][C:13]2[CH:19]=[CH:20][C:21]([Cl:22])=[C:11]([Cl:10])[CH:12]=2)[N:17]=1

Participants

5

Reactant 3

HCID 8176993-Aminopyrazine-2-carbonitrileHCID 3638364HCID 3638364, compoundHCID 19794673N,N-dimethylformamide ethanol

Product 1

HCID 10543796HCID 10543796, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Obtained using the procedure described in section c of Example 2, starting with 9.6 g (0.080 mole) of 3-amino-2-pyrazinecarbonitrile and 26.3 g (0.12 mole) of 2-(3,4-dichlorophenoxy)acetamidine in 520 ml of absolute ethanol. Refluxing time: 3 hours. Yld: 18.0 g (70%), m.p. 261°-263° C. (ethanol/N,N-dimethylformamide).

Workup

  1. customObtained
  2. temperatureRefluxing time
  3. custom3 hours

Sources & evidence

ORD record
ord-62b1b2fa36f54e32bb214b9277edadeb
Source dataset
uspto-grants-1993_12
Patent number
US05270465

Reaction notes

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