HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminopyrazine-2-carbonitrile → 4-Amino-2-[(4-methylphenoxy)methyl]pteridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminopyrazine-2-carbonitrile | HCID 817699 | — |
| Reactant | 2-(4-Methylphenoxy)acetamidine | HCID 13430822 | — |
| Reactant | Acetone ethanol | HCID 21889777 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Amino-2-[(4-methylphenoxy)methyl]pteridine | HCID 10587889 | — |
Reaction Steps
Obtained using the procedure described in section c of Example 2, starting with 6.9 g (0.057 mole) of 3-amino-2-pyrazinecarbonitrile and 14.1 g (0.086 mole) of 2-(4-methylphenoxy)acetamidine [prepared according to C. Djerassi and C. R. Scholz, U.S. Pat. No. 2,517,468; C.A. 1951, 45, 661f] in 350 ml of absolute ethanol. Refluxing time: 2 hours. Yld: 2.6 g (17%), m.p. 225°-227° C. (acetone/ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05270465 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-1e08b584bc8d4f4cbe3a062944c9c19e |
| Source note | uspto-grants-1993_12 |