3-Aminopyrazine-2-carbonitrile → HCID 10850551, compound

HRID 326861Notes

Reaction equation

HRID 326861 reaction equation
[NH2:1][C:2]1[C:3]([C:8]#[N:9])=[N:4][CH:5]=[CH:6][N:7]=1.[CH2:10]([S:17][CH2:18][C:19](N)=[NH:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(O)C>[NH2:9][C:8]1[C:3]2[C:2](=[N:7][CH:6]=[CH:5][N:4]=2)[N:1]=[C:19]([CH2:18][S:17][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:20]=1

Participants

4

Reactant 2

HCID 8176993-Aminopyrazine-2-carbonitrileHCID 18967941HCID 18967941, compound

Product 1

HCID 10850551HCID 10850551, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 2.3 g (0.019 mole) of 3-amino-2-pyrazinecarbonitrile and 5.2 g (0.029 mole) of 2-(benzylthio)acetamidine [prepared according to J. M. McManus, J. Heterocycl. Chem. 1968, 5, 137] in 150 ml of absolute ethanol is refluxed for 2 hours. After cooling, the solution obtained is concentrated to dryness under reduced pressure. The residue is washed with isopropyl ether and dried under reduced pressure. An amorphous solid is obtained, and is used in the next step without further purification. Yld: 5.4 g (quantitative).

Workup

  1. temperatureis refluxed for 2 hours
  2. temperatureAfter cooling
  3. customthe solution obtained
  4. concentrationis concentrated to dryness under reduced pressure
  5. washThe residue is washed with isopropyl ether
  6. customdried under reduced pressure
  7. customAn amorphous solid is obtained
  8. customis used in the next step without further purification

Sources & evidence

ORD record
ord-bfea307082de46eba2a15c650f417e6f
Source dataset
uspto-grants-1993_12
Patent number
US05270465

Reaction notes

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