反应详情

A suspension of 15.1 g (0.113 mole) of 3-amino-6-methyl-2-pyrazinecarbonitrile [prepared according to E. C. Taylor et al., J. Am. Chem. Soc. 1973, 95, 6413] in the above ethanolic solution of 2-ethoxyacetamidine is refluxed for 2 hours. After cooling, the solution obtained is concentrated to dryness under reduced pressure. The residue is purified by washing with acetone and recrystallization from a mixture of acetone and isopropyl ether Yld: 8.4 g (34%), m.p. 166°-168° C.

1. temperatureis refluxed for 2 hours
2. temperatureAfter cooling
3. customthe solution obtained
4. concentrationis concentrated to dryness under reduced pressure
5. customThe residue is purified
6. washby washing with acetone and recrystallization from a mixture of acetone and isopropyl ether Yld