Acetone → HCID 14880142, compound

HRID 326865Notes

Reaction equation

HRID 326865 reaction equation
[NH2:1][C:2]1[C:3]([C:8]#[N:9])=[N:4][CH:5]=[CH:6][N:7]=1.[OH:10][CH2:11][CH2:12][O:13][CH2:14][C:15](N)=[NH:16].CC(C)=O>C(O)C>[NH2:9][C:8]1[C:3]2[C:2](=[N:7][CH:6]=[CH:5][N:4]=2)[N:1]=[C:15]([CH2:14][O:13][CH2:12][CH2:11][OH:10])[N:16]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 8176993-Aminopyrazine-2-carbonitrileHCID 19736206HCID 19736206, compound

Product 1

HCID 14880142HCID 14880142, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent3×

Procedure

Obtained using the procedure described in section c of Example 2, starting with 16.0 g (0.133 mole) of 3-amino-2-pyrazinecarbonitrile and the above solution of 2-(2-hydroxyethoxy)acetamidine in absolute ethanol. Refluxing time: 2 hours 30 minutes. Yld: 20.5 g (70%), m.p. 149°-151° C. (ethanol). An analytical sample was obtained by recrystallization from a mixture of acetone and ethanol. M.p. 159°-161° C.

Workup

  1. customObtained
  2. temperatureRefluxing time
  3. custom2 hours 30 minutes

Sources & evidence

ORD record
ord-1819c96a40b44c0ea2fa6f32a6626079
Source dataset
uspto-grants-1993_12
Patent number
US05270465

Reaction notes

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