反应详情

温度

80 °C

8.1 g (0.0322 mole) of 4-amino-7-methoxy-2-(methoxymethoxymethyl)pteridine are added to a solution of 3.2 g (0.080 mole) of sodium hydroxide in 130 ml of water. The suspension obtained is heated at 80° C. for 2 hours. After filtration while hot, the solution is allowed to return to room temperature and is then acidified with acetic acid. The precipitate formed is isolated by filtration. It is purified by washing with water and then with acetone and is recrystallized from a mixture of methanol and N,N-dimethylformamide. Yld: 4.4 g (58%), m.p. 210°-212° C.

1. customThe suspension obtained
2. filtrationAfter filtration while hot, the solution
3. customto return to room temperature
4. customThe precipitate formed
5. customis isolated by filtration
6. customIt is purified
7. washby washing with water
8. customwith acetone and is recrystallized from a mixture of methanol and N,N-dimethylformamide