Sodium Hydroxide → HCID 178499629, compound

HRID 326871Notes

Reaction equation

HRID 326871 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[N:7][C:8]([O:12]C)=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:14][O:15][CH2:16][O:17][CH3:18])[N:3]=1.[OH-].[Na+]>O>[NH2:1][C:2]1[C:11]2[C:6](=[N:7][C:8]([OH:12])=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:14][O:15][CH2:16][O:17][CH3:18])[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 148801434-Amino-7-methoxy-2-(methoxymethoxymethyl)pteridine

Product 1

HCID 178499629HCID 178499629, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

8.1 g (0.0322 mole) of 4-amino-7-methoxy-2-(methoxymethoxymethyl)pteridine are added to a solution of 3.2 g (0.080 mole) of sodium hydroxide in 130 ml of water. The suspension obtained is heated at 80° C. for 2 hours. After filtration while hot, the solution is allowed to return to room temperature and is then acidified with acetic acid. The precipitate formed is isolated by filtration. It is purified by washing with water and then with acetone and is recrystallized from a mixture of methanol and N,N-dimethylformamide. Yld: 4.4 g (58%), m.p. 210°-212° C.

Workup

  1. customThe suspension obtained
  2. filtrationAfter filtration while hot, the solution
  3. customto return to room temperature
  4. customThe precipitate formed
  5. customis isolated by filtration
  6. customIt is purified
  7. washby washing with water
  8. customwith acetone and is recrystallized from a mixture of methanol and N,N-dimethylformamide

Sources & evidence

ORD record
ord-f72b61b20b3c454e8c6fab7311287566
Source dataset
uspto-grants-1993_12
Patent number
US05270465

Reaction notes

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