Morpholine → 5-Methylsulfamoyl-2-morpholin-4-yl-benzoic acid

HRID 32688Notes

Reaction equation

HRID 32688 reaction equation
CS(C1C=CC(N2CCCC2)=C(C=1)C(O)=O)(=O)=O.Cl[C:20]1[CH:28]=[CH:27][C:26]([S:29](=[O:33])(=[O:32])[NH:30][CH3:31])=[CH:25][C:21]=1[C:22]([OH:24])=[O:23].[NH:34]1[CH2:39][CH2:38][O:37][CH2:36][CH2:35]1>>[CH3:31][NH:30][S:29]([C:26]1[CH:27]=[CH:28][C:20]([N:34]2[CH2:39][CH2:38][O:37][CH2:36][CH2:35]2)=[C:21]([CH:25]=1)[C:22]([OH:24])=[O:23])(=[O:33])=[O:32]

Participants

4

Reactant 3

HCID 8083MorpholineHCID 111724Benzoic acid, 2-chloro-5-[(methylamino)sulfonyl]-HCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

Product 1

HCID 597934965-Methylsulfamoyl-2-morpholin-4-yl-benzoic acidYield 40%

Procedure

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-methylsulfamoyl-benzoic acid and morpholine and obtained in 40% yield. MS (m/e): 299.2 (MH−, 100%).

Workup

  1. customobtained in 40% yield

Sources & evidence

ORD record
ord-6d41b741667f445f8b180933432a8627
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Reaction notes

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