Morpholine → 5-(Cyclopropylmethyl-sulfamoyl)-2-morpholin-4-yl-benzoic acid

HRID 32691Notes

Reaction equation

HRID 32691 reaction equation
CS(C1C=CC(N2CCCC2)=C(C=1)C(O)=O)(=O)=O.Cl[C:20]1[CH:28]=[CH:27][C:26]([S:29](=[O:36])(=[O:35])[NH:30][CH2:31][CH:32]2[CH2:34][CH2:33]2)=[CH:25][C:21]=1[C:22]([OH:24])=[O:23].[NH:37]1[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1>>[CH:32]1([CH2:31][NH:30][S:29]([C:26]2[CH:27]=[CH:28][C:20]([N:37]3[CH2:42][CH2:41][O:40][CH2:39][CH2:38]3)=[C:21]([CH:25]=2)[C:22]([OH:24])=[O:23])(=[O:36])=[O:35])[CH2:34][CH2:33]1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 290355802-Chloro-5-(cyclopropylmethyl-sulfamoyl)-benzoic acidHCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

Product 1

HCID 597935855-(Cyclopropylmethyl-sulfamoyl)-2-morpholin-4-yl-benzoic acidYield 33%

Procedure

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-(cyclopropylmethyl-sulfamoyl)-benzoic acid and morpholine and obtained in 33% yield. MS (m/e): 339.2 (MH−, 100%).

Workup

  1. customobtained in 33% yield

Sources & evidence

ORD record
ord-11e7349391db427aa8f0b88c2e719f51
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Reaction notes

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