Methyl iodide → methyl 3-(R)-hydroxy-2-(S)-methylbutanoate

Participants

Reaction Steps

This compound was prepared according to the procedure of Example 127, but the methyl 3-(R)-hydroxybutanoate was first alkylated with methyl iodide as described by Keck et al., (J. Org. Chem., 1985, 4317) to give methyl 3-(R)-hydroxy-2-(S)methylbutanoate. The latter was transformed into the thiol according to the procedure of Example 127.

Provenance & Evidence