Sodium Acetate → HCID 135749779, compound

Participants

Reaction Steps

Sodium nitrite (3.6 g) was dissolved in concentrated sulfuric acid (25 ml) with slight warming. After cooling the solution was diluted with a mixture of acetic and propionic acids (5/1 50 ml). 2-Mesyloxy- 4-nitroaniline (11.6 g) was added portionwise with vigorous stirring. After 2 hours another portion of 5/1 acid was added and the diazonium solution kept at 5° C. while a solution of 2-amino-3-hydroxy-5-isopropylsulfamoylpyridine (11.5 g) in aqueous acetic acid (1/1 500 ml) containing sodium acetate (100 g) was being prepared. The diazonium solution was slowly added to the coupler solution at 5° C. and the reaction mixture stirred for 1 hour and then diluted with water. The dye was filtered off washed with a large volume of water and dried in a vacuum oven. Yield 26.8 g of the desired material and some inorganic salts.

Provenance & Evidence