Morpholine → 3-(4-(4-acetyl-2-fluorophenyl)piperazine-1-carbonyl)-N-methyl-4-morpholinobenzenesulfonamide

HRID 32698Notes

Reaction equation

HRID 32698 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[C:20]([S:25]([NH:28][CH3:29])(=[O:27])=[O:26])[CH:21]=[CH:22][C:23]=3Cl)=[O:17])[CH2:12][CH2:11]2)=[C:6]([F:30])[CH:5]=1)(=[O:3])[CH3:2].[NH:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1>>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[C:20]([S:25]([NH:28][CH3:29])(=[O:27])=[O:26])[CH:21]=[CH:22][C:23]=3[N:31]3[CH2:36][CH2:35][O:34][CH2:33][CH2:32]3)=[O:17])[CH2:12][CH2:11]2)=[C:6]([F:30])[CH:5]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 597936063-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-chloro-N-methyl-benzenesulfonamide

Product 1

HCID 445805543-(4-(4-acetyl-2-fluorophenyl)piperazine-1-carbonyl)-N-methyl-4-morpholinobenzenesulfonamide

Procedure

The title compound was prepared according to the procedure described for example 1 from 3-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-chloro-N-methyl-benzenesulfonamide and morpholine (58%, light yellow solid, MS (m/e): 503.1 (M−H, 100%)

Sources & evidence

ORD record
ord-8c0187994e4c4be28ff95cbad1bfb48c
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Reaction notes

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