Potassium Hydroxide → HCID 22849349, compound

HRID 326985Notes

Reaction equation

HRID 326985 reaction equation
C([O:4][CH2:5][C@@:6]12[C@@H:23]3[C@H:14]([C@H:15]4[C@@:19]([CH2:21][CH2:22]3)([CH3:20])[CH:18]=[CH:17][CH2:16]4)[CH2:13][CH2:12][C:11]1=[CH:10][C:9](=[O:24])[CH2:8][CH2:7]2)(=O)C.[OH-].[K+]>CO>[OH:4][CH2:5][C@@:6]12[C@@H:23]3[C@H:14]([C@H:15]4[C@@:19]([CH2:21][CH2:22]3)([CH3:20])[CH:18]=[CH:17][CH2:16]4)[CH2:13][CH2:12][C:11]1=[CH:10][C:9](=[O:24])[CH2:8][CH2:7]2

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 53766784HCID 53766784, compound

Product 1

HCID 22849349HCID 22849349, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

19-Acetoxyandrosta-4,16-dien-3-one (17) is treated with potassium hydroxide in methanol (i). Aqueous work-up is followed by extraction and purification to yield the alcohol (18).

Workup

  1. extractionAqueous work-up is followed by extraction and purification

Sources & evidence

ORD record
ord-ccc47c89bc1042f9b88686fc243e571e
Source dataset
uspto-grants-1993_12
Patent number
US05272134

Reaction notes

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