Morpholine → 3-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-N,N-dimethyl-4-morpholin-4-yl-benzenesulfonamide

HRID 32700Notes

Reaction equation

HRID 32700 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[C:20]([S:25]([N:28]([CH3:30])[CH3:29])(=[O:27])=[O:26])[CH:21]=[CH:22][C:23]=3Cl)=[O:17])[CH2:12][CH2:11]2)=[C:6]([F:31])[CH:5]=1)(=[O:3])[CH3:2].[NH:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1>>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[C:20]([S:25]([N:28]([CH3:30])[CH3:29])(=[O:27])=[O:26])[CH:21]=[CH:22][C:23]=3[N:32]3[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)=[O:17])[CH2:12][CH2:11]2)=[C:6]([F:31])[CH:5]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 417707503-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-chloro-N,N-dimethyl-benzenesulfonamide

Product 1

HCID 597936403-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-N,N-dimethyl-4-morpholin-4-yl-benzenesulfonamide

Procedure

The title compound was prepared according to the procedure described for example 1 from 3-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-chloro-N,N-dimethyl-benzenesulfonamide and morpholine (60%, light yellow solid, MS (m/e): 519.2 (M+H, 100%)

Sources & evidence

ORD record
ord-7e31e5fd3fd24c8483754ee27a24f224
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Reaction notes

Loading…