HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 19734388, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-Amino-4,6-dichloropyrimidine | HCID 79434 | — |
| Reactant | (5-(Aminomethyl)furan-2-yl)methanol | HCID 448213 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 19734388 | HCID 19734388 | 76.6% |
Reaction Steps
A mixture of 16.3 parts of 4,6-dichloro-5-pyrimidinamine, 14 parts of 5-(aminomethyl)-2-furanmethanol, 12 parts of N,N-diethylethanamine and 200 parts of water was stirred for 10 hours at reflux temperature. The reaction mixture was evaporated and the residue was purified by column chromatography (silica gel; CH2Cl2 /CH3OH(NH3) 95:5). The eluent of the desired fraction was evaporated and the residue was crystallized from acetonitrile. The product was filtered off and dried, yielding 19.5 parts (76.6%) of 5-[[(5-amino-6-chloro-4-pyrimidinyl)amino]methyl]-2-furanmethanol; mp. 136.7° C. (interm. 17).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05272150 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-a4d7ede076264065ab31026220d6d670 |
| Source note | uspto-grants-1993_12 |